SOCE deficiency in drosophila resulting from Stim or Orai downregulation impairs the flight capacities (Venkiteswaran and Hasan, 2009; Agrawal et al., 2010), and zebrafish embryos injected with mRNA containing STIM1 or ORAI1 GoF mutations display thrombocytopenia (Nesin et al., 2014), highlighting the conservation of SOCE in specific tissues. Here, ORAI1 is linked to Thrombocytopenia.