STIM1 and Thrombocytopenia: Mice harboring the Stim1 GoF mutations D84G, I115F, or R304W show a varying degree of multi-systemic disease signs including small size (Cordero-Sanchez et al., 2019; Silva-Rojas et al., 2019), eye movement defects (Silva-Rojas et al., 2019), skin and spleen anomalies (Grosse et al., 2007; Cordero-Sanchez et al., 2019; Silva-Rojas et al., 2019), bleeding diathesis with thrombocytopenia (Grosse et al., 2007; Cordero-Sanchez et al., 2019; Silva-Rojas et al., 2019), and muscle weakness (Cordero-Sanchez et al., 2019; Silva-Rojas et al., 2019).