In contrast, dominant STIM1 and ORAI1 gain-of-function (GoF) mutations inducing excessive Ca2+ entry through SOCE over-activation were found in patients with tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK) (Bohm et al., 2013; Misceo et al., 2014; Morin et al., 2014; Nesin et al., 2014). This evidence concerns the gene ORAI1 and tubular aggregate myopathy.