Mutations in ITPR2 and ITRP3, respectively, encoding IP3R types 2 and 3, are associated with anhidrosis in patients (Klar et al., 2014; Kerkhofs et al., 2018), and the same phenotype is also observed in Itpr2 and Itpr3 double knockout mice (Futatsugi et al., 2005). Here, ITPR2 is linked to anhidrosis.