It was reported that ANO1 forms a direct complex with EGFR through the trans/juxtamembrane domain of EGFR in head and neck squamous cell carcinoma (HNSCC) cells; knockdown of ANO1 resulted in greatly reduced EGFR protein levels, which functionally translated to decreased cell proliferation (Bill et al., 2015). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.