The most recognized cellular functions of ANO1 include the control of cancer cell proliferation, survival and migration by ANO1 (Bill and Alex Gaither, 2017; Crottes and Jan, 2019), secretory function of ANO1 in the epithelia, such as airways, intestines, salivary glands, renal tubules and sweat glands (Jang and Oh, 2014), induction of electrical pacemaker activity of interstitial cells of Cajal in gastrointestinal smooth muscles (Sanders et al., 2012), control of acute pain sensation, chronic pain and anxiety-related behaviors (Oh and Jung, 2016; Cho et al., 2020), and contribution. Here, ANO1 is linked to Anxiety.