Alpha-arbutin anti-inflammation properties in the field of neurogenerative disease and disorders such as Parkinson and Alzheimer diseases (Dadgar et al., 2018; Ding et al., 2020) were observed, and in our study, APOE4 is downregulated too, which highlights the similar response on alpha-arbutin treatment in different cells. Here, APOE is linked to Alzheimer disease.