Greka’s lab recently used complementary organoid and in vivo models to study this proteinopathy, and demonstrated an intracellular accumulation of mutant MUC1 transmembrane protein in tubular cells of mutant transgenic mice, as well as in human MKD samples and hiPSC-derived organoids from patients (Dvela-Levitt et al., 2019). Here, MUC1 is linked to mevalonic aciduria.