Evidence indicates that TMEPAI expression in these tumors acts to counteract cell proliferation (Singha et al., 2014; Fournier et al., 2015; Li et al., 2015; Du et al., 2018; Abdelaziz et al., 2019), but this activity is highly dependent on tumor origin (Rae et al., 2001; Giannini et al., 2003; Vo Nguyen et al., 2014; Singha et al., 2019). Here, PMEPA1 is linked to neoplasm.