Alpha subunit protein kinase B (AKT1) is an important member of the AKT family, and current studies have confirmed that AKT1, as an important regulatory factor, is in a state of disorder in various tumors, such as prostate cancer, osteosarcoma, ovarian cancer, and endometrial cancer, leading to uncontrolled proliferation of tumor cells, apoptosis defects, and enhanced metastasis and invasion ability of tumor (Alwhaibi et al., 2019; Huo et al., 2019; Wang J. et al., 2019). Here, AKT1 is linked to osteosarcoma.