Several lines of evidence suggested the inflammatory risk factors (Trefoil Factor 3, neutrophils, lymphocytes, et al.)in PD may modulate underlying neurodegeneration particularly in relation to dementia (Stojkovic et al., 2018; Zou et al., 2018; Nicoletti et al., 2020; Wang et al., 2020). This evidence concerns the gene TFF3 and Parkinson disease.