To conclude, our study has revealed the pathological profile of soluble 4R0N tau overexpression in cells, which recapitulates some of the earliest phenotypes observed in AD clinical cases such as endolysosomal dysfunction and autophagic stress (Orr and Oddo, 2013; Whyte et al., 2017; Colacurcio et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.