This result should also be considered in the light of previous evidence showing a reduction of microglia activation following celastrol (Dai et al., 2019) or indomethacin (Lopes et al., 2016) administration, as well as a strict interrelation between TNF-α and IL-1ß and redox dysregulation in CNS disorders (Fischer and Maier, 2015; Schiavone and Trabace, 2017). This evidence concerns the gene IL1B and central nervous system disorder.