These findings support the idea that the pathogenesis and progression of these tauopathies are closely associated with the formation of disease-specific tau strains or folded conformers, and with cell-to-cell transmission of the pathological proteins (Goedert et al., 2018; Fitzpatrick and Saibil, 2019; Hasegawa, 2019). The gene discussed is MAPT; the disease is tauopathy.