In PSP, CBD, GGT, and AGD, 4R tau isoforms selectively accumulate in neuronal and glial cells, and the filaments in each disease have unique filamentous morphologies, such as SFs (13–14 nm) in PSP and wide, twisted filaments (20 nm) in CBD (Iwatsubo et al., 1994; Spillantini et al., 1997; Hutton et al., 1998; Poorkaj et al., 1998; Buee and Delacourte, 1999; Goedert and Hasegawa, 1999; Lee et al., 2001; Kovacs, 2015). This evidence concerns the gene MAPT and red-green color blindness.