In addition, the complement system is also activated in patients with heart failure, which may be related to the direct activation of classical pathways and complement bypass pathways by necrotic or damaged spinous cells, or to the activation of complement by CRP in patient plasma (Frey et al., 2013[12]; Orrem et al., 2018[25]; Suffritti et al., 2017[33]). The gene discussed is CRP; the disease is heart failure.