Regarding the relationship between the high level of dynamin 2 in the nucleus and the tumor stage, it should be stated that, high levels of ErbB2 in the nucleus has been shown to act as a transcriptional coactivator of Stat3 (signal transducer and activator of transcription 3) for promoting the cyclin D1 expression and c-myc oncogene (Ralhan et al., 2010[34]; Xia et al., 2011[41]; Liu et al., 2018[26]). The gene discussed is CCND1; the disease is neoplasm.