EZH2 and cancer: Interestingly, there were significant differences in the expression levels of several previously reported tolerance-related gene targets in cancer cells, such as EZH2, KDM5, KDM6, and HDACs. 14,17,19 Moreover, gene sets involved in histone modification and chromatin remodelling were significantly enriched (Fig. 3b and Table S5), indicating that epigenetic alterations mediate the reversible phenotype in MM patients.