Fine et al. report that patients who receive an infusion of paclitaxel prior to BM surgery show a significant concentration of taxane in the metastatic tissue, particularly at the centre of the metastases:34 2507 ng/gm tumour for an estimated therapeutic level of >1000 ng/gm.27 Dijkers et al. have shown that [89Zr]-trastuzumab can be detected in BM at the same median concentration than in bone metastasis of patients with HER2+ MBC.35 However, the results of Lockman et al. and Dijkers et al. in humans revealed a large variability of concentrations in BMs. The gene discussed is ERBB2; the disease is neoplasm.