Here, we found that intra-hippocampal inoculation of human AD brain extracts to huAPPwt mice, a model that expresses humanized non-mutated forms of AβPP and does not spontaneously develop amyloid deposits, induces slight Aβ deposition in regions surrounding the alveus but not in other parts of the hippocampus or brain regions. The gene discussed is APP; the disease is Alzheimer disease.