Notably, RA patients exhibited significantly higher levels of MPO‐DNA complexes and NE‐DNA complexes than healthy controls (0.50 [0.40–1.05] vs 0.40 [0.30–0.60], and 0.70 [0.50–1.00] vs 0.60 [0.50–1.30], RU, median [interquartile range]; p = 0.009 and p < 0.001, Figure 1A,B). This evidence concerns the gene MPO and rheumatoid arthritis.