The most studied enzyme is probably choline kinase (CHKA), the initial step of this pathway, which is a target of the hypoxia-inducible factor (HIF)-1a (Glunde et al. 2008), stimulated by oncogenic signals, and overexpressed in several tumor types (Glunde, Bhujwalla, and Ronen 2011). The gene discussed is CHKA; the disease is neoplasm.