The previous study considered that the correlation between the clinical and cardiac changes with galectin-3 level give an indirect proof supporting a probable function for galectin-3 in the pathogenesis of cardiac remodeling in HF, and demonstrated that after an early injury to the cardiac muscles compensatory mechanism of cardiac remodeling occurs, leading to left ventricular dysfunction and HF [17]. Here, LGALS3 is linked to hydrops fetalis.