retrospectively studied patients with resected PC and a pathogenic germline mutation in BRCA1, BRCA2, and PALB2. 105Median OS in mutation carriers exposed to platinum in the perioperative setting was not reached versus 23.1 months in wild type patients (HR 0.12; 95% CI, 0.01-1.00). This evidence concerns the gene BRCA1 and pachyonychia congenita.