Previous reports on DNAm in pigmentation/skin cancer‐associated regions include a study by Roos and colleagues (Roos et al., 2017) who showed that DNAm in healthy human skin was associated in cis with SNPs underlying melanoma risk discovered by GWAS, including two polymorphisms in MC1R (rs258322, rs4785763, which we tested) and one in the ASIP region (rs910873, not considered by us but in LD with rs619865). This evidence concerns the gene MC1R and skin neoplasm.