And qualitative criteria regarding drug prescription to consider IP (the prescription of sulphonylureas (SU) was considered inappropriate due to their high risk of hypoglycaemia [21, 23]; patients with doses of metformin not adjusted for renal failure [21]; patients with gliflozins (SGLT2 inhibitors) and renal failure (glomerular filtration rate (GFR) < 45 ml/min) [21, 24] and, the use of insulins associated with the highest risk of hypoglycaemic episodes (short-acting insulins, mixtures and postprandial use) was considered inappropriate, except in justified cases [21]). The gene discussed is SLC5A2; the disease is Renal insufficiency.