BASP1 and neoplasm: However, previous reports have shown that BASP1 is downregulated in v-myc-induced transformed cells, and that overexpression of BASP1 inhibits transformation, further analysis showed that BASP1 inhibits the target genes of c-Myc, such as WS5, Q83 and BRAK, suggested that BASP1 could be a tumor suppressor (Hartl et al., 2009).