The presence of TP53 mutation pattern in PC can be a worthy diagnostic tool for the identification of a subset of patients that may undergo a treatment regimen since some studies showed a role of mutant TP53 in the signaling pathways such as RTK (Adorno et al., 2009; Sauer et al., 2010; Wang et al., 2013). Here, TP53 is linked to pachyonychia congenita.