According to the previous investigations, the identification of BRAF and TERT promoter mutation in thyroid nodules enabled preoperative stratification of the surgical treatment, leading to total thyroidectomy and most likely prophylactic central lymph node dissection if the clinicopathological setting is appropriate (Melo et al., 2014; Paschke et al., 2017; Trimboli et al., 2016; Xing, 2013). The gene discussed is TERT; the disease is thyroid nodule.