IDH1 and glioblastoma: In fact, a meta-analysis comparing IHC with DNA sequencing in 1360 cases of glioblastoma showed that the pooled sensitivity and specificity for IDH1 IHC were 1.00 (95% CI 0.82–1.00) and 0.99 (95% CI 0.96–1.00), respectively (Pyo et al., 2016).