Regarding the association between HR-HPV and p16INK4a as well as Ki-67 expression, most researchers believe that p16INK4a is a surrogate marker for CIN induced by HR-HPV and that HR-HPV negative status accompanied by p16INK4a positivity is often regarded as a false negative (Zong et al., 2015). This evidence concerns the gene MKI67 and cervical squamous intraepithelial neoplasia.