The coexpression of p16INK4a and Ki-67 was developed as an auxiliary marker of cervical pre-cancers (Kanthiya et al., 2016; Sundström et al., 2013) but a series of studies reported that an increased risk of high grade CIN or cervical cancer is associated with high HPV DNA loads, suggesting that HPV is a marker to predict cervical neoplasia (Lim et al., 2016 ; Zong et al., 2015 ; Nam et al., 2008). The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.