The overexpression of p16INK4a in cervical dysplasia was reported to be associated with the transforming activity of the E7 oncoprotein of HR-HPV types through inactivation of the tumor-suppressor function of the retinoblastoma protein (pRb) (Thomsen et al., 2015). The gene discussed is RB1; the disease is cervical intraepithelial neoplasia.