In order to further understand the molecular circuitry involved in TC2N molecular loops, we investigated correlation between TC2N expression and selected genes in 10 cancer pathways namely, Myc pathway, cell cycle pathway, p53 pathway, Nrf2 pathway, Wnt pathway, Hippo pathway, TGFβ pathway, Notch pathway, PI3K pathway and RTK/RAS pathway. The gene discussed is TP53; the disease is cancer.