TLR4 and Sepsis: This finding is consistent with that reported by Schnetzke et al., (2015) who reported that The presence of the TLR2 Arg753Gln polymorphism was significantly associated with pneumonia in AML patients and that the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia.