AML patients who have TLR2 (Arg753Gln) GG genotype had the shortest OS; followed by those have AG and AA genotypes (P=0.001); while TLR4 (Thr399Ile and Asp299Gly) polymorphism did not affect the OS (P=0.06; 0,104 respectively). The gene discussed is TLR4; the disease is acute myeloid leukemia.