We found that AML patients who have TLR2 Arg753Gln: AG genotypes and A allele; TLR4 Asp299Gly: CT genotype and C allele; TLR4 Thr399Ile AG genotype and A allele showed significant higher association to sepsis and pneumonia as compared to other genotypes and alleles. Here, TLR4 is linked to acute myeloid leukemia.