AKT1 and cancer: Understanding of upstream regulators, Downstream targets and in vivo functions of AKT promote the treatment of the diseases generated (cancer (Avan et al., 2014; De Marco et al., 2013; Kim et al., 2012), diabetes (Devaney et al., 2011), as well as schizophrenia (Norton et al., 2007; Ikeda et al., 2004), ...).