In the study by Kim et al., (2010), who evaluated the association between a set of 14 polymorphisms of PI3K/PTEN/AKT/mTOR pathway genes and CRC, no association was observed, between the selected SNPs of this pathway (including rs1130214 and rs2494737) and survival of patients with colorectal adenocarcinoma. This evidence concerns the gene AKT1 and colorectal carcinoma.