PTEN and colorectal carcinoma: In the study by Kim et al., (2010), who evaluated the association between a set of 14 polymorphisms of PI3K/PTEN/AKT/mTOR pathway genes and CRC, no association was observed, between the selected SNPs of this pathway (including rs1130214 and rs2494737) and survival of patients with colorectal adenocarcinoma.