In SGPA and adenoid cystic carcinoma, the slight, but relevant difference in incidence between males and females (female to male incidence ratio of 1.4:1 and 1.2:1, respectively) and the overexpression of estrogen β receptor (ER‐β), compared to normal salivary gland, may suggest a role for the proliferative influence of estrogens in tumorigenesis.2, 14, 53. This evidence concerns the gene ESR2 and adenoid cystic carcinoma.