Environmental factors could be MUC7, MUC5B, MUC1 and their saccharide residues; these molecules, excreted to the intercellular space for not completely clear reasons, stimulate the secretion of inflammatory and pro-inflammatory molecules and activate the Toll-like receptors that also participate in the inflammatory reaction, however, a correlation between cytokines and MUC would only partially explain the etiopathogenesis of pSS. Here, MUC1 is linked to peeling skin syndrome.