Importantly, licochalcone A–mediated survivin down‐regulation is partly dependent on the suppression of EGFR downstream Akt and ERK1/2 signallings, which is consistent with the previous report that reduces survivin protein by brexpiprazole overcomes EGFR TKI resistance in lung and pancreatic cancer.53 This evidence concerns the gene MAPK3 and pancreatic neoplasm.