Importantly, licochalcone A–mediated survivin down‐regulation is partly dependent on the suppression of EGFR downstream Akt and ERK1/2 signallings, which is consistent with the previous report that reduces survivin protein by brexpiprazole overcomes EGFR TKI resistance in lung and pancreatic cancer.53 Here, AKT1 is linked to familial pancreatic carcinoma.