Liver cell‐derived exosomes carry liver‐specific proteins and miRNAs, such as carboxylesterase‐1 (CES1), alcohol dehydrogenase‐1 (ADH1), glutathione S‐transferase, apolipoprotein A‐1 (APOA1), albumin (ALB), haptoglobin (HP) and miRNA‐122,11 which can be used as potential biomarkers and targets in liver disease. Here, APOA1 is linked to liver disorder.