Noteworthy, the association between basal copeptin and PCVS was confirmed at different multivariate models also including CPB (OR 1.15, 95% CI 1.009–1.32), clamping time (OR 1.16, 95% CI 0.996–1.36), severe CKD (OR 1.15, 95% CI 1.021–1.31) or diuretic treatment (OR 1.17, 95% CI 1.03–1.33). Here, AVP is linked to chronic kidney disease.