Among the proteins involved in the Alzheimer's disease and Parkinson's disease pathways, in addition to the fact that we already know that COX7B, COX6A2 and UQCRQ affect the function of mitochondria, downregulation of CASP9 is thought to lead to neurodegenerative diseases30. The gene discussed is CASP9; the disease is early-onset autosomal dominant Alzheimer disease.