PPBP and central nervous system disorder: The central nervous system disorders may not only be caused directly by upregulation of COX7B and downregulation of COX6A2, UQCRQ, and CASP9, but also due to indirect regulation of CCL3L1, CCL19, CXCL6, CCL25, and PPBP (both in the cytokine–cytokine receptor interaction and chemokine signaling pathways).