PTPN11 and acute lymphoblastic leukemia: Our data reveal that reducing RAS activity via inhibition of PTPN11 catalytical action may provide a functional alternative for ALL cells, while blocking the phosphorylation of PTPN11 via JAK inhibitors was not sufficient to prevent RAS activity, and concordantly with our mechanistic insight was also unable to block the direct interaction between PTPN11 and RAS.