As we see examples of RAS-mutated, wtRAS, or JAK2-mutated DS-ALL in each of the profile types (Fig. 4c), with exception of low-RAS and non-inducible type, we can conclude that activity levels and TSLP-inducibility of RAS cannot be predicted on the basis of DNA-sequencing (acquired mutations) patterns. This evidence concerns the gene JAK2 and acute lymphoblastic leukemia.