The upregulated genes included CYP4F3, IL1RL1, PTGS2, and CXCL8, which are related to inflammation; HKDC1, MYEF2 and CYP1A1, which are related to hepatocarcinoma or lung carcinoma; and SLC7A11 and NEFM, which are related to neuronal damage. The gene discussed is NEFM; the disease is lung carcinoma.