F2RL1 and cancer: This is consistent with previous studies showing that Il-8 secretion in airway epithelial cells is regulated by PAR2-mediated activation of PLCβ/Ca2+ pathway55, and that neutrophil adhesion to lung A549 cancer cells is enhanced via the reorganization of actin and cytoskeleton through Rho/ROCK- and FAK-dependent pathways upon PAR2 stimulation56.