We found that liposomal Y27632 downregulated adhesion signaling (SRC and FAK) in MM and BMME cells in vitro, reduced trans-endothelial migration of MM cells in vitro, and increased mobilization of MM cells in vivo; the effect of liposomal Y27632 was similar to or greater than that of free Y27632 (Fig. 5). The gene discussed is PTK2; the disease is Miyoshi myopathy.