In addition to the genetic evidence for Kcnn3 and anxiety-related and alcohol drinking behaviors, we found a complex and polygenic trait architecture through genetic mapping of the Kcnn3 “anxiety” eigentrait with evidence of regulation by loci on Chr 1 and 13. The Chr 1 locus contained single-nucleotide polymorphisms in the Cacna1e gene that encodes R-type Ca2+ channels. This evidence concerns the gene KCNN3 and Anxiety.