PSCA and Familial prostate cancer: In fact, co-author Dr. Peter Nelson used whole-genome/transcriptional profiling of 140 prostate cancer metastases to establish that prostate tumor lesions exhibit heterogeneous expression of three key cell-surface proteins (prostate-specific membrane antigen (PSMA), prostate stem cell antigen (PSCA), and receptor tyrosine kinase-like orphan receptor 1 (ROR1) among patients (Fig. 7a).