HLA-A and hepatocellular carcinoma: All mice reproducibly developed multifocal lesions within 7 days (Fig. 8a), at which point they were reconstituted with unstimulated human 10 × 106 CD3+ human HLA-A*02:01T cells and received two weekly infusions of nanoparticles loaded with mRNA (50 μg/dose) encoding the HBcore18–27 TCR to generate HCC specificity or control particles loaded with mRNA encoding GFP.