Following an intravenous booster dose of ROR1-CAR-encoding mRNA nanoparticles the same day, the tumor lesions were again infiltrated by freshly reprogrammed peripheral blood T cells (average 1066 ± 225 CAR+ T cells/mg tumor on day 11; Fig. 7h), which recapitulates the oscillating kinetics of mRNA nanoparticle-induced T-cell reprogramming we already observed in our leukemia studies (Fig. 4e). The gene discussed is ROR1; the disease is neoplasm.