The six subgroups were characterized and defined by (1) lower BMI, mild or no evidence of radiographic knee OA (ROA), and lower hs-CRP (minimal joint disease subgroup); (2) dominantly male, mild or moderate ROA, and higher T-score (male and high BMD subgroup); (3) mild or moderate ROA and higher hs-CRP (high CRP subgroup); (4) most severe ROA (K/L grade ≥ 2) and lowest T-score (severe ROA subgroup); (5) moderate ROA and severe depression (depressive subgroup); and (6) higher BMI and moderate or severe ROA (moderate ROA with high BMI subgroup). This evidence concerns the gene CRP and major depressive disorder.