Glial fibrillary acidic protein (GFAP), a marker of retinal gliosis [50, 51] which is upregulated upon MP activation [52] and used as an index of retinal degeneration, was dramatically increased throughout most of the entire retina (Fig. 1b); this effect was largely prevented by rytvela and Kineret. The gene discussed is GFAP; the disease is retinal degeneration.