CD4 and autoimmune disease: With the limitations of a different model of autoimmune disease, experimental autoimmune myocarditis, we have observed that OA did not trigger significant differences in the proportion of CD3+, CD4+, and CD8+ T cells; CD14+ macrophages/monocytes; and CD19+ B cells; however, OA-treatment significantly increased the percentage/proportion of Treg, compared to control mice [12].