SOAT1 and inborn error of immunity: As expected, the immune-associated pathways were highly enriched in immunity-high, including cytokine–cytokine receptor interactions, intestinal immune network for IgA production, natural killer cell-mediated cytotoxicity, leukocyte transendothelial migration, chemokine signaling, Toll-like receptor signaling, Jak–STAT signaling, antigen processing and presentation, B and T cell receptor signaling, NOD-like receptor signaling, Fc gamma R-mediated phagocytosis, apoptosis, Fc epsilon RI signaling, and primary immunodeficiency (Fig. 5a).