TGFB1 and malignant colon neoplasm: Similarly, another study also validated that MALAT1, which is highly expressed in colon cancer tissues, promotes SW480 and HCT116 colon cancer cell growth via binding miR-663a and upregulating several targets of miR-663, including TGF-β1, PIK3CD, p53, p21, and JUND [63].