NPC1L1 and hyperlipidemia: It was also shown to suppress postprandial hyperlipidemia more strongly than fenofibrate in mice fed a high-fat diet by inhibiting mRNA expression of apolipoprotein B-48 (APOB-48), intestinal cholesterol transporter Nieman-Pick C1-like 1 (NPC1L1) and microsomal triglyceride transfer protein in the small intestine.