EGFR and lung adenocarcinoma: Several reports have shown that curcumin inhibits EGFR signaling via suppression of EGFR expression, induction of EGFR degradation, inhibition of kinase activity of EGFR, and modulation of EGFR dimerization in lung adenocarcinoma, colon cancer, and epidermoid carcinoma cell lines [19, 21, 41].