Although the effect of the TET2 V1846F variation in tumorigenesis is not clear, cells with only one normal TET2 allele may have a growth advantage under KIT D816A expression, even after deletion of the TET2 V1846F allele in our current patient, suggesting that the TET2 V1846F variant was unlikely to have affected the tumor progression. This evidence concerns the gene KIT and neoplasm.