Expression of genes associated with endocytic function, cytoskeleton organization, and positive regulators of endocytosis, such as 1-phosphatidylinositol-4-phosphate 5-kinase (Pip5klc), phospholipase D1/2 (Pld2), integrin subunit beta1 (Itgb1), GTPase Hras, clathrin adaptor protein (Dab2), caveolin1 (Cav1), and E3 ligase NEDD4 (Nedd4) were higher in LSECs than in KCs (Additional file 2). The gene discussed is CAV1; the disease is dry eye syndrome.